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Recombinant prolactin helps augment lactation |
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Written by Reuters Health
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Friday, 10 August 2007 |
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 NEW YORK -- Recombinant human prolactin (rhPRL) is showing promise as an aid to lactation, according to a pilot study by Massachusetts-based researchers.
"While this study is the first to examine the activity and safety profile of rhPRL, and more extensive investigation is needed," lead investigator Dr. Gabrielle Page-Wilson told Reuters Health, "we are nonetheless excited about the implications of these early data."
In a study published online July 24 in the International Breastfeeding Journal, Dr. Page-Wilson of Harvard Medical School, Boston, and colleagues note that the majority of studies demonstrate a relationship between prolactin levels and poor breastfeeding. Low basal and suckling-stimulated prolactin concentrations are also seen in women with low milk production.
To examine the effects of rhPRL, the team conducted a double-blind study with 21 healthy women who had regular menstrual periods and were not postpartum. The women were randomized to receive a daily injection of rhPRL or placebo for 7 days. Their breasts were then examined for the presence of expressible galactorrhea by palpation.
Prolactin levels increased significantly during rhPRL administration and five of the nine women who received the active agent developed expressible galactorrhea.
The team notes that due to the large calcium requirements of lactation, markers of bone formation and resorption are increased in women during lactation. However, in the group studied, there was no apparent adverse effect on bone turnover or on their menstrual cycle.
"Lactation insufficiency in newly lactating women is a really common problem, and this preliminary data makes us hopeful that in the future we may be able to safely use rhPRL to enhance breast milk production, Dr. Page-Wilson noted, "allowing mothers with otherwise inadequate milk supplies to fully meet their infant's nutritional needs."
See also: Dr. Page-Wilson's article from the International Breastfeeding Journal, July 24, 2007.
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